IMO...with this test there is always still a chance that "clear" dogs still have a chance of getting Cardio. Along with VetGen Vwd testing (which we all know is not foolproof)...how do I trust the test for "clear" Cardio! I pay $90 for Vwd testing (and that is at a "group" discount)...Paying $60 for something that would change the longevity in my Dobes and breeding program is VERY reasonable. BUT, do I trust it too? I have never believed in Holtering...no offense to anyone doing this...but, when you do holtering for a 24 hr period on a Stud dog and the next week he drops dead a week later of Cardio...I have a problem with the procedure of holter montering.
OK...I'm off my soapbox
The website address for more information and to order tests is
http://www.vetmed.ws...erman/test.aspxThe tests are available NOW. They are $60 per dog, or if you
have 5+ dogs then $51 per dog.
So. The gene is an Autosomal Dominant gene, with incomplete penetrance.
Just as I thought. What does that mean?
1. They found the gene by discovering that dogs who have Cardio are missing
a large chunk of a particular DNA strand which makes a protein that produces
energy to fuel the heart muscle.
2. If they have one copy of this mutated gene, they will not produce enough
of that particular protein to keep their heart functioning forever, and
eventually MAY develop the disease. If they have two copies of the mutated
gene, they produce even less of this protein, and MAY/USUALLY develop the
disease, usually earlier, and more severe.
3. If they test negative, they have no mutated gene, and are consider
'clear'. They may still develop cardio at some point in their lives, but it
is unlikely and would likely be a different disease, or caused by an
additional disease. Advise: Breed to these dogs.
4. If they test positive for one copy of the mutated gene, they are
considered 'positive heterozygus'', or Carriers. This means they MAY develop
Cardio at some point in their lives usually later, and will pass on an
affected gene to 50% of their offspring. Advise: Breed these dogs only to
'clears'. Try to obtain clears from the following generation to breed
instead.
5. If they test positive for two copies of the mutated gene, they are
considered 'positive homozygus', or Affected. This means they very likely
WILL develop Cardio, and usually early in life in it's most severe form.
They will pass on a mutated copy of the gene to 100% of their offspring.
Advise: Do not breed these dogs.
So, because this gene has incomplete penetrance, they feel that there is a
chance that environment/diet/supplements etc, may play a role in if the
disease ever manifests in that dog. Further study required on that. They
may NEVER get it, even if they have the mutated gene. But, at least by
testing we have a direction to go in